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Back to top Hypothermic Techniques: When and WherePresented by Stephan A. Mayer, MD

There is probably no clinical condition in medicine today which engenders a more overwhelming sense of clinical nihilism than hypoxic-ischemic coma. The role of the clinician in managing these patients has, until very recently, been restricted to prognostication, and little else. Fortunately, with the advent of early induced hypothermia, which is now feasible in the critical care environment, this is changing.

Late-Breaking Clinical Trials and Trial Updates: Novel Therapies for Acute Myocardial InfarctionPresented by Gregg W. Stone, MD, F.A.C.C.
William W. O’Neill, MD, F.A.C.C.
Menko Jan de Boer, MD, F.A.C.C.
Dan Tzivoni, MD, F.A.C.C.
Michel R. LeMay, MD, F.A.C.C.
Tomasz Siminiak, MD, Ph.D., F.A.C.C.

This summary highlights key data from the EMERALD, AMIHOT, On-Time, CAPITAL AMI, and POZNAN trials.

Patients at Risk for Recurrent Embolism After Percutaneous Closure of Patent Foramen Ovale for Presumed Paradoxical EmbolismPresented by Markus Schwerzmann, MD

Risk for recurrent embolic events after percutaneous closure of patent foramen ovale (PFO) was increased in patients with multiple cardiovascular risk factors, and in patients with 2 or more thromboembolic events prior to device implantation. These findings may help elucidate which patients are at low risk for recurrent events after PFO closure, and therefore benefit most from percutaneous PFO closure.

Urinary Tract Infection in Patients with Acute Coronary syndrome: A Potential Systemic connectionPresented by John B. Sims, MD

In patients with acute coronary syndromes, subclinical urinary tract infections (UTIs) are more common than in a group of patients awaiting bypass surgery, results of this retrospective, case-control study suggest. Subclinical infection may be a trigger for ACS, perhaps via activation of systemic inflammation.

The multicenter evaluation of the everolimus-eluting stent for inhibition of neointimal hyperplasia: Results of the pooled FUTURE I and II trialsPresented by Ricardo A. Costa, MD

This summary looks at a pooled analysis of the FUTURE I and II data, with angiographic endpoints of in-stent late loss and binary restenosis assessed at 6 months follow-up.

Women with Diabetes Mellitus Have the Greatest Reduction in Myocardial Infarction Mortality Over the Past Decade: Evaluation of 1, 428,596 Patients Enrolled in the Natioanl Registry of Myocardial Infarction 2, 3 and 4 from 1994-2002Presented by Darren McGuire MD, MHSc

The goal of this analysis was to evaluate short-term mortality trends during the past decade among patients with MI according to DM status, especially among women with DM; trends in the prevalence of DM among MI patients; and trends in the use of evidence-based therapies.

Impact of the Angiotensin-Receptor Blocker Candesartan in Preventing Diabetes in Patients with Heart FailurePresented by Salim Yusuf, DPhil

Inhibitors of the renin-angiotensin-aldosterone system (RAAS) have been shown to prevent the development of diabetes in various groups of patients at increased risk of cardiovascular events. This summary looks at the impact of the angiotensin receptor blocker candesartan in preventing diabetes in patients with heart failure

Percutaneous Pulmonary ValvesPresented by Philipp Bonhoeffer, MD

Non-surgical valve replacement may soon become a reality for the replacement of cardiac valves. For pulmonary valve replacement, data to date suggest that percutaneous delivery of a biological valve is possible, is safe, and may have an important role in managing conduit obstructions and pulmonary regurgitation.

The IL-6 -174G/C polymorphism is a powerful predictor for restenosis after coronary stent implantationPresented by Tanja Kottmann, MD

The aim of this study was to investigate which polymorphisms are significant predictors for restenosis after ST and which mechanisms can be identified to increase restenosis.

Late Breaking Clinical Trials IPresented by Donald Hunninghake, MD
Stefan Hohnloser, MD
Rahul Doshi, MD
Gust Bardy, MD
Christopher Cannon, MD

This summary highlights key data from the PROVE-IT TIMI 22, PAVE, ALLIANCE, SCD-HeFT and DINAMIT trials.

Should Statin Therapy Be Used Routinely in Pediatric Heart Transplant Recipients?Presented by William T. Mahle, MD

It is unclear whether statin therapy should be routinely used in the pediatric heart transplant population. The aim of this retrospective analysis was to determine whether such statin therapy would reduce the risk of developing CAV in these children.

Association of Triglyceride to High-Density Lipoprotein Cholesterol Ratio With Heart Rate Recovery in Healthy Adults Presented by Mehdi H. Shishehbor, DO
Michael S. Lauer, MD

Investigators have identified significant association between heart rate recovery and TG/HDL-C ratio. In a retrospective analysis, the two factors together identify patients with insulin resistance who are at increased risk of death. By performing simple lipid measures and an exercise test, clinicians can obtain information that may be prognostically important in clinical practice.

Similar Outcomes Between Patients with Native Coronary and Bypass Graft Disease Treated with Sirolimus-Eluting Stents in the SECURE Trial Presented by Marco Costa, MD

As part of the compassionate-use SECURE trial, the long-term results using sirolimus-eluting stents were compared in patients with native coronary disease vs. those with bypass graft disease.

Alterations in Cell Signaling Pathways During Pregnancy and Postpartum Cardiac Remodeling : Interventions in Patients with Diabetes Presented by Ana M. Duque Gonzalez, MD

The objective of this study was to determine the role of MAPK activation and/or Akt, in mediating cardiac remodeling during pregnancy and post-partum.

Late Breaking Clinical Trials II Presented by Robert M. Anthenelli, M.D.
Barry M. Massie, M.D., F.A.C.C.
Ted E. Feldman, M.D., F.A.C.C.
Franz H. Messerli, M.D., F.A.C.C.
Curt D. Furberg MD, PhD
Kenneth Mahaffey, MD, M.D., F.A.C.C.
Robert M. Califf, M.D., F.A.C.C.
James Ferguson, MD, M.D., F.A.C.C.
Jean-Pierre Despres, PhD

This summary highlights key data from the SYNERGY, STRATUS-US, WATCH,INVEST and other important trials.

The Superior Yield of the New Strategy of Enoxaparin, Revascularization and Glycoprotein IIb/IIIa Inhibitors (SYNERGY) Trial: Primary Results Presented by Kenneth W. Mahaffey, M.D., F.A.C.C.
James J. Ferguson, M.D., F.A.C.C.
Robert M. Califf, MD, F.A.C.C.

The purpose of the Superior Yield of the New Strategy of Enoxaparin, Revascularization, and Glycoprotein IIb/IIIa Inhibitors (SYNERGY) trial was to compare enoxaparin to unfractionated heparin as primary antithrombotic therapy in high-risk non-ST-elevation myocardial infarction (NSTEMI) ACS patients managed with an early invasive treatment strategy and to determine the role of enoxaparin in this population.

Long-Term Follow-Up of Safety and Feasibility of Autologous Skeletal Myoblast Transplantation in Patients Undergoing Coronary Artery Bypass Graft Surgery Presented by Nabil Dib, MD

The primary purpose of this study was to evaluate the safety and feasibility of autologous myoblast transplantation AMT into and around ischemic myocardium during coronary artery bypass (CABG) surgery in humans.

Long-term effects of statin therapy in patients with acute ST-elevation myocardial infarction and moderate or severe left ventricular dysfunction: Reduction of mortality but not of nonfatal major adverse coronary and cerebrovascular events Presented by Thomas Kleemann, MD

This trial was undertaken to evaluate the prognostic impact of early statin therapy in patients with moderate or severe left ventricular dysfunction (ejection fraction <40%) after acute ST-elevation MI.

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The Duke Treadmill Score and Cardiac Mortality in Asymptomatic Women: The St. James Women Take Heart Project Presented by Martha Gulati, MD, MS


Cardiovascular Morbidity and Mortality in Patients with Diabetes in the EUROPA Study: Results from the PERSUADE Substudy Presented by Prof. Kim M. Fox

This EUROPA substudy shows that in diabetics, perindopril offers a similar relative risk reduction, and a greater absolute benefit, compared with the main study population of patients with stable coronary disease without heart failure. The effect of perindopril in diabetics appeared to be independent of the reduction in blood pressure achieved by the drug.

Magnet Therapy and the Autonomic Nervous System Presented by Benjamin J. Scherlag, PhD

The therapeutic use of magnets have been promoted for various medical conditions. What is less well known is the use of electromagnetic fields (EMFs) for the diagnosis and treatment of ailments using established scientific protocols. In this study, investigators applied specific, low-level EMFs to the cervical vagosympathetic trunks, which provide the major autonomic nerve inputs to the heart.

Late-Breaking Clinical Trials III Presented by Prof. Kim M. Fox, MD
Thomas A. Pearson, MD, PhD, FACC
Peter H. Stone, MD, FACC
Kim A. Eagle, MD, FACC
John J. Mahmarian, MD, FACC

This summary highlights key data from the PERSUADE, INSPIRE and other important trials.

EASE Trial: Ezetimibe Add-on to Statin for Effectiveness Trial Presented by Thomas A. Pearson, MD, PhD

The Ezetimibe Add-on to Statin for Effectiveness (EASE) trial was undertaken to examine the effectiveness and safety of ezetimibe, 10 mg, compared with placebo, added to any statin brand and dose in patients who were not at their NCEP ATP III LDL cholesterol goal despite statin monotherapy.




  
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